Publications

We have publications in the following fields of research. Click the topic to get to the subsection you are interested in:

Biomedically relevant Systems

Electrostatics in Biology

Biological Membranes

Functional Interfaces

Proteins/Co-Factors

Preprints
Peer-reviewed Publications
  1. Z. Ji, J. Kozuch, I. I. Mathews, C. S. Diercks, Y. Shamsudin, M. A. Schulz, S. G. Boxer*
    Protein electric fields enable faster and longer-lasting covalent inhibition of beta-lactamases
    J. Am. Chem. Soc., 2022, 144, 20947-20954.
    https://doi.org/10.1021/jacs.2c09876
  2. T. Utesch, J. K. Staffa, S. Katz, G. Yao, J. Kozuch,* P. Hildebrandt*
    Potential distribution across model membranes
    J. Phys. Chem. B, 2022. 126, 7664-7675.
    https://doi.org/10.1021/acs.jpcb.2c05372
  3. C. Zheng, Y. Mao, J. Kozuch, A. Atsango, Z. Ji, T. Markland,* S. G. Boxer*
    Electric field orientations in solution and enzyme active site revealed by a two-dimensional vibrational probe
    Nat. Chem., 2022, 14, 891-897.
    https://doi.org/10.1038/s41557-022-00937-w
  4. J. B. Weaver, J. Kozuch, J. M. Kirsh, S. G. Boxer*
    Nitrile IR intensities characterize electric fields and hydrogen bonding in protic, aprotic, and protein environments
    J. Am. Chem. Soc., 2022, 144, 7562–7567.
    https://doi.org/10.1021/jacs.2c00675
  5. M. La Greca, J. L. Chen, L. Schubert, J. Kozuch, T. Berneiser, U. Terpitz, J. Heberle, R. Schlesinger*
    The Photoreaction of the Proton-Pumping Rhodopsin 1 From the Maize Pathogenic Basidiomycete Ustilago maydis
    Front. Mol. Biosci., 2022, 9, 829660.
    https://doi.org/10.3389/fmolb.2022.826990

    2021
  6. S. H. Schneider, J. Kozuch, S. G. Boxer*
    The interplay of electrostatics and chemical positioning in the evolution of antibiotic resistance in TEM beta-lactamases
    ACS Cent. Sci., 2021, 7, 1996-2008.
    https://doi.org/10.1101/2021.05.27.446023
  7. A. Kraskov, J. Von Sass, A. D. Nguyen, T. O. Hoang, D. Buhrke, S. Katz, N. Michael, J. Kozuch, I. Zebger, F. Siebert, P. Scheerer, M. A. Mroginski,* N. Budisa,* P. Hildebrandt,*
    Electric Field Changes during the Photoconversion of the Bathy Phytochrome Agp2
    Biochemistry, 2021, 60, 2967-2977.
    https://doi.org/10.1101/2021.05.27.446023
  8. J. Kozuch,* S. H. Schneider, C. Zheng, Z. Ji, R. T. Bradshaw, S. G. Boxer*
    Testing the limitations of MD-based local electric fields using the vibrational Stark effect in solution: pencillin G as a test case
    J. Phys. Chem. B, 2021, 125, 4415-4427.
    https://doi.org/10.1021/acs.jpcb.1c00578
  9. F. Baserga, J. Drageli, J. Kozuch, H. Mohrmann, E.-W. Knapp. S. T. Stripp, J. Heberle*
    Quantification of local electric field changes in the active site of cytochrome c oxidase by FTIR spectroelectrochemical titrations
    Front. Chem., 2021, 9, 669452.
    https://doi.org/10.3389/fchem.2021.669452

    2020
  10. J. Kozuch, S. H. Schneider, S. G. Boxer*
    Biosynthetic incorporation of site-specific isotopes in β-lactam antibiotics enables biophysical studies
    ACS Chem. Bio., 2020, 15, 1148-1153.
    https://doi.org/10.1021/acschembio.9b01054
  11. U. Szczepaniak, S. H. Schneider, R. Horvath, J. Kozuch, M. Geiser*
    Vibrational Stark spectroscopy of fluorobenzene using quantum cascade laser dual frequency combs
    Appl. Spec., 2020, 74, 347-356.
    https://doi.org/10.1177/0003702819888503

    2019
  12. A. de Miguel Catalina, E. Forbrig, J. Kozuch, C. Nehls, L. Paulowski, T. Gutsmann, P. Hildebrandt,* M. A. Mroginski*
    The C-terminal VPRTES tail of LL-37 influences the mode of attachment to a lipid bilayer and antimicrobial activity
    Biochemistry, 2019, 58, 2447-2464.
    https://doi.org/10.1021/acs.biochem.8b01297

    2018
  13. M. Caterino, M. Herrmann, A. Merlino, C. Ricciardi, D. Montesarchio, M. A. Mroginski, D. Musumeci, F. Ruffo, L. Paduano, P. Hildebrandt, J. Kozuch,* A. Vergara*
    On the pH-modulated Ru-based pro-drug activation mechanism Inorg. Chem., 2018, 58, 1216-1223.
    https://doi.org/10.1021/acs.inorgchem.8b02667
  14. H. Biava, T. Schreiber, S. Katz, J.-S. Völler, M. Stolarski, C. Schulz, N. Michael, N. Budisa, J. Kozuch,* T. Utesch,* P. Hildebrandt*
    Long-range modulations of the electric fields in proteins
    J. Phys. Chem. B, 2018, 122, 8330-8342.
    https://doi.org/10.1021/acs.jpcb.8b03870
  15. T. G. G. A. Harris, N. Heidary, J. Kozuch, S. Frielingsdorf, O. Lenz, M. A. Mroginski, P. Hildebrandt, I. Zebger,* A. Fischer*
    In situ spectroelectrochemical studies into the formation and stability of robust diazoniumderived interfaces on gold electrodes for the immobilization of an oxygen-tolerant hydrogenase
    ACS Appl. Mater. Interfaces, 2018, 10, 23380-23391. https://doi.org/10.1021/acsami.8b02273
  16. O. Gutierrez-Sanz, E. Forbrig, A. P. Batista, M. I. Pereira, J. Salewski, M. A. Mroginski, R. Götz, A. L. De Lacey, J. Kozuch,* I. Zebger*
    Catalytic activity and proton translocation of reconstituted respiratory complex I monitored by surface-enhanced infrared absorption spectroscopy
    Langmuir, 2018, 34, 57023-5711. https://doi.org/10.1021/acs.langmuir.7b04057
  17. P. Kielb, M. Horch, P. Wrzolek, R. Götz, H. K. Ly, J. Kozuch, M. Schwalbe, I. Weidinger*
    Hydrogen Evolution by cobalt hangman porphyrins under operating conditions studied by vibrational spectro-electrochemistry
    Catal. Sci. Technol., 2018, 8, 1849-1857.
    https://doi.org/10.1039/C7CY02253K
  18. E. Forbrig, J. K. Staffa, J. Salewski, M. A. Mroginski, P. Hildebrandt, J. Kozuch*
    Monitoring the orientational changes of alamethicin during incorporation in bilayer lipid membranes
    Langmuir, 2018, 34, 2373-2385.
    https://doi.org/10.1021/acs.langmuir.7b04265

    2017
  19. J. K. Staffa, L. Lorenz, M. Stolarski, D. H. Murgida, I. Zebger, T. Utesch, J. Kozuch,* P. Hildebrandt*
    Determination of the local electric field at Au/SAM interfaces using the vibrational Stark effect
    J. Phys. Chem. C, 2017, 121, 22274-22285.
    https://doi.org/10.1021/acs.jpcc.7b08434
  20. P. Kielb, T. Utesch, J. Kozuch, J.-H. Jeoung, H. Dobbek, M. A. Mroginski, P. Hildebrandt, I. Weidinger*
    Switchable redox chemistry of the hexameric tyrosine-coordinated heme protein
    J. Phys. Chem. B, 2017, 121, 3955-3964.
    https://doi.org/10.1021/acs.jpcb.7b01286

    2016
  21. S. Wiebalck, J. Kozuch,* C. C. Tzschucke, L. J. C. Jeuken, P. Hildebrandt*
    Monitoring the transmembrane proton gradient generated by cytochrome bo3 in tethered bilayer lipid membranes using SEIRA spectroscopy
    J. Phys. Chem. B, 2016, 120, 22492256.
    https://doi.org/10.1021/acs.jpcb.6b01435

    2015
  22. H. K. Ly, P. Wrzolek, N. Heidary, R. Götz, M. Horch, J. Kozuch, M. Schwalbe,* I. Weidinger*
    2nd coordination sphere controlled electron transfer of iron hangman complexes on rlectrodes probed by surface-enhanced vibrational spectroscopy
    Chem. Sci., 2015, 6, 6999-7007.
    https://doi.org/10.1039/C5SC02560E
  23. J. Kozuch,* N. Petrusch, D. Gkogkou, U. Gernert, I. M. Weidinger*
    Calculating average surface-enhancement factors of randomly nanostructured electrodes by a combination of SERS and impedance Spectroscopy
    Phys. Chem. Chem. Phys., 2015, 17, 21220-21225.
    https://doi.org/10.1039/C4CP05015K

    2014
  24. J. Kozuch,* C. Weichbrodt, D. Millo, K. Giller, S. Becker, P. Hildebrandt,* C. Steinem Voltage-dependent structural changes of the membrane-bound anion channel hVDAC1 probed by SEIRA and electrochemical impedance spectroscopy
    Phys. Chem. Chem. Phys., 2014, 16, 9546-9555.
    https://doi.org/10.1039/C4CP00167B

    2014
  25. X. X. Han, C. Köhler, J. Kozuch, U. Kuhlmann, L. Paasche, A. Sivanesan, I. M. Weidinger, P. Hildebrandt*
    Potential-Dependent surface-enhanced resonance Raman spectroscopy at nanostructured TiO2: a case study on cytochrome b5
    Small, 2013, 9, 4175-4181.
    https://doi.org/10.1002/smll.201301070
  26. J. Kozuch, I. von der Hocht, F. Hilbers, H. Michel, I. M. Weidinger*
    Resonance Raman Characterization of the ammonia-generated intermediate of cytochrome c oxidase from Paracoccus denitrificans.
    Biochemistry, 2013, 52, 6197-6202. https://doi.org/10.1021/bi400535m

    2013
  27. J. Kozuch, C. Steinem, P. Hildebrandt,* D. Millo*
    Combined electrochemistry and surface-enhanced infrared absorption spectroscopy of gramicidin A incorporated into tethered bilayer lipid membranes
    Angew. Chem. Int. Ed., 2012, 51, 8114-8117.
    https://doi.org/10.1002/anie.201203214
  28. A. Sivanesan, J. Kozuch, H. K. Ly, G. Kalaivani, A. Fischer, I. M. Weidinger*
    Tailored silica coated Ag nanoparticles for non-invasive surface enhanced Raman spectroscopy of biomolecular targets
    RSC Adv., 2012, 2, 805-808.
    https://doi.org/10.1039/C1RA00781E

    2012
  29. A. Sivanesan, H. K. Ly, J. Kozuch, M. Sezer, U. Kuhlmann, A. Fischer, I. M. Weidinger*
    Functionalized Ag nanoparticles with tunable optical properties for selective protein analysis
    Chem. Commun., 2011, 47, 3553-3555.
    https://doi.org/10.1039/C0CC05058J