Evolution Towards Antibiotic Resistance through Electrostatics and Chemical Positioning

Paper accepted in ACS Central Scienice on Electrostatics and Chemical Positioning in Enzymes Evolution towards Antibiotic Resistance

What are the physical origins of antibiotic resistance? Using experiments and theory we explore the active site electric fields and chemical positioning in β-lactamases.

Schneider & Kozuch et al., ACS Centr. Sci., 2022, 7, 1996-2008
The Interplay of Electrostatics and Chemical Positioning in the Evolution of Antibiotic Resistance in TEM β-Lactamases.
DOI: 10.1021/acscentsci.1c00880

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