‘In Situ Spectroscopic Detection of Large-Scale Reorientations of Transmembrane Helices During Influenza A M2 Channel Opening’ published in Angew. Chem.

Viroporins are viral ion channels that play important role during viral infection and, thus, present important drug targets. Using SEIRA spectroscopy we monitor the activity of Influenza A M2 proton channel in a model membrane and identify the mechanical opening of the channel as a transition to a more ‘fanned out’ structure.

DOI: 10.1002/anie.202309069