Category Archives: Allgemein

‘In Situ Spectroscopic Detection of Large-Scale Reorientations of Transmembrane Helices During Influenza A M2 Channel Opening’ published in Angew. Chem.

Viroporins are viral ion channels that play important role during viral infection and, thus, present important drug targets. Using SEIRA spectroscopy we monitor the activity of Influenza A M2 proton channel in a model membrane and identify the mechanical opening of the channel as a transition to a more ‘fanned out’ structure. DOI: 10.1002/anie.202309069

Review on ‘Surface-enhanced Infrared Absorption Spectroscopy’ in Nat. Rev. Methods Primers

As part of an invitation by Nature Reviews Methods Primers we have published together with Ken Ataka and Joachim Heberle a review on the method of ‘Surface-enhanced Infrared Absorption Spectroscopy’, SEIRAS. SEIRAS enhanced IR spectra at interface by 102 – 107 and, thus, allows to study single-layered assemblies. We discuss the basics, important experimental considerationContinue reading “Review on ‘Surface-enhanced Infrared Absorption Spectroscopy’ in Nat. Rev. Methods Primers”

Open PhD position in Experimental Molecular Biophysics of Protein Misfolding in Neurodegenerative Diseases

PhD position (m/f/d) in Experimental Molecular Biophysics of protein folding and misfolding in neurodegenerative diseases at the Freie Universität Berlin (65% TV-L E13, 36 month) We are again looking for a motivated student who is interested in exploring biomedically relevant, physico-chemical concepts of protein/peptide (mis)folding trajectories at lipid membranes. This will be studied using surface-enhancedContinue reading “Open PhD position in Experimental Molecular Biophysics of Protein Misfolding in Neurodegenerative Diseases”

Open PhD position in Computational and Experimental Biophysics of Antibiotic Resistance

PhD position (m/f/d) in Computational and Experimental Biophysics of Antibiotic Resistance at the Freie Universität Berlin (65% TV-L E13, 36 month) We are looking for motivated students who enjoy bridging experimental and computational methods in biophysical chemistry or biophysics. You will explore the physico-chemical concepts of how electric field-driven catalysis enables the degradation of antibioticsContinue reading “Open PhD position in Computational and Experimental Biophysics of Antibiotic Resistance”

DFG Individual Research Project Granted

Understanding Antibiotic Resistance and Enzymatic Catalysis by Combining Computational and Experimental Molecular Biophysics We will explore the relationship between the evolution of antibiotic resistance and the physical forces or non-covalent interactions that exist within enzymatic catalysts. Towards this goal, we will make use of a combined approach of computational and experimental vibrational spectroscopy in defined,Continue reading “DFG Individual Research Project Granted”